Advanced glycation end-products
Advanced glycation end-products (AGEs) are irreversible adducts and cross-links formed when reducing sugars or reactive carbonyls non‑enzymatically modify proteins, lipids, or nucleic acids. AGEs accumulate with aging and in hyperglycemia, alter tissue mechanics, activate inflammatory pathways via receptors such as RAGE, and are implicated in diabetic complications, cardiovascular, renal, skeletal, and neurodegenerative disorders.
