Pareidolia is a psychological phenomenon where individuals perceive familiar patterns, such as faces or objects, in random stimuli. This tendency is rooted in the brain's pattern recognition capabilities and has been observed across various cultures and historical periods.

The Receptor for Advanced Glycation End Products (RAGE) is a multiligand cell-surface receptor of the immunoglobulin superfamily encoded by the AGER gene on human chromosome 6p21.3 within the major histocompatibility complex. It binds diverse damage-associated ligands, including advanced glycation end-products, S100 proteins, HMGB1, amyloid-β, and nucleic acids, and activates pro‑inflammatory signaling pathways implicated in chronic disease.