Receptor for Advanced Glycation End Products
The Receptor for Advanced Glycation End Products (RAGE) is a multiligand cell-surface receptor of the immunoglobulin superfamily encoded by the AGER gene on human chromosome 6p21.3 within the major histocompatibility complex. It binds diverse damage-associated ligands, including advanced glycation end-products, S100 proteins, HMGB1, amyloid-β, and nucleic acids, and activates pro‑inflammatory signaling pathways implicated in chronic disease.
